Pricing and availability. Pricing is rumored to be anywhere from $299 to $499 - expect a "subscription" only version that will feature a lower upfront cost, but require a monthly subscription to Xbox Live Gold. And as far as availability - expect "later this year" which code for "Fall/in time for Christmas".
Games, games, games, games, games, games and more games. Microsoft flubbed it with the last keynote by not really appealing to core gamers. I fully expect Microsoft to right the ship today.
I'm hoping they'll provide more details on the pricing structure surrounding the used games as well as licensing to hopefully clear up some of the confusion.
I expect some hints or outright announcement about a new revamped Xbox 360.
There have been rumors of a "set top box" version of the Xbox that's meant only for media streaming (à la Roku) but it's not expected to be launched until next year.